Posaconazole

About This Test

Department: Virology and Molecular Microbiology

Requirement:

5ml clotted blood (1ml if paediatric)

Turnaround Time:

1-2 days

Assay to determine level of posaconazole in serum for therapeutic monitoring

Other Comments:

State time of last dose and time of sample

Measurement units: mg/L
Clinical decision points: By HPLC assay
Prophylaxis: Pre 0.7-1.5 mg/L
Therapy: Pre 1.0-2.0 mg/L
Vermes et al. 2000. Journal of Antimicrobial Chemotherapy 46: 171-179. Ashbee et al. 2014. J. Antimicrobial Chemotherapy 69:1162-1176.
Andes et al. 2009. Antimicrobial Agents and Chemotherapy 53: 24-34.
Dolton et al. 2012. Antimicrobial Agents and Chemotherapy 56: 2806-2813.

Factors known to significantly affect results: Haemolysis
Reference Lab: PHE Bristol