There is only one clinical building at County Hospital and six clinical buildings at Royal Stoke University Hospital, these include: Main Building, Trent Building, Lyme Building, Cancer Centre, Maternity Centre, West Building, Cancer Centre and Maternity Centre.

All patients and visitors attending Main Building and the adjacent Trent and Lyme buildings are asked to use the Main Entrance. As the Royal Stoke University Hospital is built upon a slight incline, not every floor of the hospital are present on the seven storey's. The main entrance has a WHSmith, Costa Coffee and self check-in screens.